From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD) have evolved as important tools to inform rational of antibiotics in individual patients with infections. In particular, critically ill display altered, highly variable pharmacokinetics often suffer from infections caused by less susceptible bacteria. Consequently, TDM has been used individualize this patient group for many years. More recently, there increasing research on the use MIPD software streamline process, which can increase flexibility dose individualization but also requires adequate model validation re-evaluation existing workflows. parallel, new minimally invasive noninvasive technologies such microneedle-based sensors are being developed, which—together software—have potential revolutionize how dosed antibiotics. Nonetheless, carefully designed clinical trials evaluate benefit approaches still sparse, needed justify implementation practice. The present review summarizes pharmacology antibiotics, conventional approaches, evidence value TDM/MIPD aminoglycosides, beta-lactams, glycopeptides, linezolid, recommended.